Correlation between circulating myeloid-derived suppressor cells and serum miRNA21 in non-small cell lung cancer and its clinical significance

Objective: To investigate the effect and clinical significance of myeloid-derived suppressor cells (MDSCs) levels serum miRNA-21 expression in advanced non-small cell lung cancer (NSCLC) patients. Methods: Advanced NSCLC patients treated at First People’s Hospital Tongxiang City, Zhejiang Province, between July 2021 June 2022 were included this study. MDSCs peripheral circulation assessed by flow cytometry, was q-PCR. The effects on MDSC proliferation ARG-1 inducible nitric oxide synthase (iNOS) secretion from examined using vitro experiments. In addition, correlation CEA, CRP Ki67 analyzed. Results: Compared with those individuals control group, polymorphonuclear-MDSCs (PMN-MDSCs) significantly higher, two groups positively correlated. experiments, mimics promoted increased iNOS inhibtor has an opposite result. PMN-MDSCs correlated carcinoembryonic antigen (CEA), C-reactive protein (CRP), Ki67. Conclusion: blood contains high miRNA-21, may interact to impact NSCLC.